실험동물
Immune Deficient Mouse Model
SID mouse (Scid mediated Immune Deficient mice)
| Model | Nomenclature | Hair | T cells | B cells | NK cells | Leakiness | Irradiation tolerance |
|---|---|---|---|---|---|---|---|
| SID(NSGA) | NOD-Prkdcem1BaekIl2rgem1Baek | Yes | No | No | No | Very low | Low |
Order Inquiry
JA BIO
- T. 031-212-8048
- F. 031-215-3294, 031-8014-2797
- E-Mail : info@jabio.co.kr
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Model characteristics
The SID model is a double knockout (Prkdc & Il2rg) mouse with complete immunodeficient phenotype. The model was created by genome scissors (CRISPR/ Cpf1 & Cas9) in Sep 13th, 2016. This mouse has a deficiency in T, B, and NK cells and shows reduced leakiness compared to SCID mice.
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Advantages
Immunodeficient phenotype enhances tumor cell acceptance and mostly can be used in PDX models and humanized mice. SID mice are available with low cost and fast delivery due to the domestic breeding with a certified health monitoring report.
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Applications
Oncology research / Cancer cell transplantation / Immunology / Humanized mouse / Immuno-cancer therapy