실험동물
Immune Deficient Mouse Model
RID mouse (Rag2 mediated Immune Deficient mice)
| Model | Nomenclature | Hair | T cells | B cells | NK cells | Leakiness | Irradiation tolerance |
|---|---|---|---|---|---|---|---|
| RID | NOD-Rag2em1BaekIl2rgem1Baek | Yes | No | No | No | Very low | High |
Irradiation tolerance
Order Inquiry
JA BIO
- T. 031-212-8048
- F. 031-215-3294, 031-8014-2797
- E-Mail : info@jabio.co.kr
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Model characteristics
The RID model is a double knockout mouse(Rag2& Il2rg) with complete immunodeficient phenotype. The model was created by genome scissors (CRISPR/Cas9) in Jun 9th, 2016. This mouse has a deficiency in T, B, and NK cells and shows reduced leakiness compared to SCID mice. Importantly, RID mice show less radiosenstivity compared to SID and SCID mice.
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Advantages
Immunodeficient phenotype enhances tumor cell acceptance and mostly can be used in PDX models and humanized mice. D mouse shows radio-resistant properties compared to NSG mice thus those mice can be utilized in the research for radiation oncology. Irradiation dose limit are approximately 5.5 Gy. mice are available with low cost and fast delivery due to the domestic breeding.
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Applications
Oncology research / Cancer cell transplantation / Immunology / Humanized mouse / Immuno cancer therapy / Radiotherapy